Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Microcystin-LF, Microcystis aeruginosa
Analog of Microcystin-LR with Phe substituted in place of Arg. Believed to be more cell-permeable than other microcystins, making it useful for biochemical studies in intact cells.
MilliporeSigma™ Calbiochem™ α-Amanitin, Amanita sp.
A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.
MilliporeSigma™ Calbiochem™ Amylin, Human
Amylin, Human, CAS 122384-88-7, is a 37-amino acid polypeptide secreted from the β cells of the pancreas. Structurally related to calcitonin. Has anorectic effects in rats.
MilliporeSigma™ Calbiochem™ Yohimbine Hydrochloride
Yohimbine Hydrochloride is a potent antagonist for α2-adrenoceptors, α2B and α2C receptors respectively).
MilliporeSigma™ Calbiochem™ Guanabenz Acetate
A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.
MilliporeSigma™ Calbiochem™ H-7, Dihydrochloride
A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.
MilliporeSigma™ Calbiochem™ Herg Activator, NS1643
The Herg Activator, NS1643, also referenced under CAS 448895-37-2, modulates the biological activity of Herg. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ DMBO
An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-α and heparin-binding-EGF in a surface plasmon resonance assay.
MilliporeSigma™ Calbiochem™ Flt-3 Inhibitor II
The Flt-3 Inhibitor II, also referenced under CAS 896138-40-2, controls the biological activity of Flt-3.
MilliporeSigma™ Calbiochem™ β-Catenin/Tcf Inhibitor IV
A cell-permeable, potent inhibitor of Tcf4-luciferase expression in both 33.13 and 22C11 cells (IC50 = 596, 690 nM, respectively). Arrests the growth of colon cancer cells.
MilliporeSigma™ Calbiochem™ ZK-756326
A highly potent and selective agonist for chemokine receptor 8 (CCR8) (IC50 values ar
MilliporeSigma™ Calbiochem™ EGFR Inhibitor II, BIBX1382
The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Forskolin, 1,9-Dideoxy-, Coleus forskohlii
Natural product that does not stimulate adenylate cyclase.